Scientific Program

The European Working Group of Myelodysplastic Syndrome Childhood (EWOG-MDS) and severe aplastic anemia (EWOG-SAA) is a consortium of National Working Groups of clinicians and researchers of 20 European Countries dedicated to diagnose and treat young individuals with acquired and inherited bone marrow failure, predisposition syndromes, MDS and rare MPD in young people.

Biannually, EWOG-MDS/SAA organizes an International Symposium to bring together renowned experts in the fields. The upcoming 11th International Symposium of EWOG-MDS/SAA will be held September 18 – 20, 2025 in Berlin, Germany.

National Coordinators and reference laboratories are the backbone of the EWOG and contribute to the Symposium.

The Symposium is a Hybrid Meeting. Content will be available for all registered participants until March 1, 2026.

Program

Thursday, 18.09.2025
07:30 – 08:30	Breakfast
08:30 – 12:00	Education Session
12:00 – 13:00	Lunch
13:00 – 13:10	Welcome
13:10 – 15:30	Aplastic anemia Keynote Lecture: The role of somatic T-cell mutations and immune dysregulation in SAA Satu Mustjoki (Helsinki, Finland) Abstract presentation Abstract presentation Abstract presentation Abstract presentation Mini Panel: Long-term consequences of therapy in aplastic anemia Setting the stage: Therapeutic concepts in pediatric SAA Carlo Dufour (Genova, Italy) Clones: Relevance of clonal hematopoiesis following IST and HSCT Mirjam Belderbos (Utrecht, The Netherlands) Cancer: Risk of malignancy following IST and HSCT Akiko Shimamura (Boston, USA) Children: Risk of infertility Ayami Yoshimi (Freiburg, Germany) Concepts: How to design long-term FUP Jean Hugues Dalle (Paris, France)
16:00 – 18:30	The path to clonal myeloid malignancy Abstract presentation Abstract presentation Abstract presentation Abstract presentation Abstract presentation Abstract presentation Keynote Lecture: How risky is clonal hematopoiesis? Luca Malcovati (Pavia, Italy) Mini Panel: Clonal hematopoiesis in aging and germline predisposition: Is it the same? Impulse statement Luca Malcovati (Pavia, Italy) Battle of clones: Somatic genetic rescue congenital in bone marrow failure disorders Akiko Shimamura (Boston, USA) Hematopoietic stem cells with monosomy 7 Marcin Wlodarski (Memphis, USA) Genetic outfit and modes of stem cell aging Julia Skokowa (Tübingen, Germany)
19:00 – 21:00	Welcome reception

Friday, 19.09.2025
07:30 – 08:30	Breakfast
08:30 – 10:00	Inherited predispositions to myeloid neoplasms and their clinical implications Keynote Lecture: GATA2 Deficiency: From pathophysiology to clinical care Marlene Pasquet (Toulouse, France) Abstract presentation Abstract presentation Keynote Lecture: Germline disorders linked to telomere maintenance and dysfunction Sharon Savage (Bethesda, USA)
10:00 – 11:30	Poster and Coffee
11:30 – 12:30	(Epi-)genomic landscape in JMML Abstract presentation Abstract presentation Abstract presentation Abstract presentation
12:30 – 13:00	Lunch + Grab a coffee
13:00 – 14:00	Mini Panel: International consensus on risk criteria in JMML One size fits all? Risk criteria and genetic groups Hélène Cavé (Paris, France) Is a DNA methylation score mandatory? Hideki Muramatsu (Nagoya, Japan) What is the role of subclonal mutations in risk definition? Elliot Stieglitz (San Francisco, USA) How many parameters do we need? Edoardo Muratore (Bologna, Italy)
14:00 – 15:00	Classification and clinical approach to overlap syndromes and rare MPDs Impulse statement Martina Rudelius (Munich, Germany) Abstract presentation Abstract presentation Abstract presentation
15:00 – 16:30	Tailoring pre- and post-HSCT therapy in advanced MDS and JMML Abstract presentation Abstract presentation Abstract presentation Opinion statement Riccardo Masetti (Bologna, Italy)
17:00	Departure for evening program

Saturday, 20.09.2025
07:30 – 08:30	Breakfast
07:30 – 08:30	EWOG Closed Meeting
08:30 – 10:00	MDS secondary to therapy Keynote Lecture: Therapy-induced clonal hematopoiesis Sam Behjati (Cambridge, UK) Abstract presentation Abstract presentation Abstract presentation Abstract presentation
10:00 – 10:30	Coffee break
10:30 – 12:30	Innovations in therapy and diagnostics Abstract presentation Abstract presentation Abstract presentation Abstract presentation Mini Panel: The future in diagnostics: From single cell to deep learning Setting the stage Marcin Wlodarski (Memphis, USA)
12:30	Adjourn

Young EWOG

Dear young colleagues, newcomers and researchers interested in EWOG topics,

We are looking forward to meeting you at the Symposium On the Verge to Malignancy: Cytopenia and Beyond of the European Working Group of Myelodysplastic Syndromes (EWOG-MDS) and Severe Aplastic Anemia (EWOG-SAA) in Childhood. The group of Young EWOG will prepare an educational session that will be the part of the sientific program.

Marc Bierings for the organizing team of the educational session